As far as
Ignored you before, now all of a sudden you exist (this can be co-workers now acknowledging you, inviting you to work parties as friends, or trying to peruse a relationship with you.
A few posters have said essentially to not give these folks a chance. But I think it can depend.
I have a friend, who I've been friends with for many years (over a decade) and its kinda an opposite situation (she's gained several, possibly up to 100 lbs, in those years). She used to dress nicely, and joke around in a positive goofy way, she used to be active and fun.
As she's gained weight she now dresses in old t-shirts that don't fit properly and sweatpants. She just wants to sit around now instead of doing stuff. And her humor has a darker edge to it. She's less pleasant to be around - not because she's fat per say - but because if we do go out, she's not meeting the dress code, or she just wants to get there and find a place and sit, or she's making biting comments under the guise of humor.
I know another guy who's always been very heavy. To the point where he can't - physically can't - fit in the backseat of a couple friend's cars. He doesn't have his own car. And well... sometimes he doesn't get invited out because people don't like having to have their SO sit in the back seat every time in a car that is half theirs, just because this guy can only sit shot gun, with the seat pushed back all the way. If he meets us where ever we are, or its a short drive, thats ok, but if its a long drive somewhere, its just physically uncomfortable to accommodate him. he's fun, he friendly, he great, but his size impedes other people's space needs.
So sometimes you have to look at what else has changed about you aside from the weight - if your co-workers now invite you out after work because now you can make it into the trendy bar with the dress code because your weight loss prompted you to dress more nicely, it might not be that they didn't want to be seen with you when you were fat or didn't like you, it might have been they didn't want you to be embarrassed being turned away at the door. If your peripheral friends invite you to the amusement park with them now but didn't when you were fat, maybe its because you didn't fit in the ride seats and couldn't keep up with an 8 hour day on your feet before. These are real, and perhaps unfortunate, but practical concerns with the very overweight that have nothing to do with not wanting to be around fat people but rather not wanting to alter plans to accommodate some of the pitfalls.
Now if people were outright mean or rude, that's different, they are just mean people who don't deserve your attention. But if they were always nice but simply didn't invite you out as much before it could have been for logistical reasons.