Please correct me if I have facts wrong:
A agrees to go out with you a few weeks after a major surgery, and less time after treatment for a DVT.
She can't drive, has stitches, and is on pain medication. She is hobbling.
She complains of feeling faint and ill.
She has alcohol.
She behaves oddly, and later can't remember it.
She get's corrected for her behavior and leaves to seek public transport home- still denying behavior that was open and obvious.
I would seriously seriously say: What the blazes was she doing drinking on pain meds? And then wandering off home alone- hobbling?
A probably should not have been out, and really really probably should not have had a drink without her doc's permission. When she started acting weird, and then denying she had invited the guys over, it was time to take her home, and probably to call the doc or call her parents just to make sure she wasn't having a drug/alcohol interaction.
I certainly can't say if she was rude or not- I have no where near enough info, but my guess would go with "something interacted".