For me, it depends. On where I'm going, when I'm going, how long I'm going for, etc. My mom lives 8 hours from me, so unless I can stay at least 4 days, its simply not worth the trip. The drive is exhausting, and takes pretty much a full day. So I generally don't get to see her more than 3 or maybe 4 times a year. Flying isn't an option as its 45 mins to the airport, then I have to park, pay to park, adn take the shuttle to the terminal. The flight itself is only 50 minutes, but then its another 45 minute drive to her house from the airport. When you factor in time to get through security, etc., driving is actually a better option.
What's funny is that now the 3 hour drive from my hometown to college seems like nothing compared to the drive to my moms!
I have a small group of HS friends who all live near where we grew up, some withing blocks of each other, and Im about 45 mins away. Generally speaking, I only get together with them on weekends, as during the week between traffic, and so on, its not worth it.
And if mom and I are traveling, driving is the only way, as she's in a wheelchair, and its the easiest way. She drives, with hand controls, so we can split it. Last fall, we drove from VA to Nashville, and next fall we are driving from VA to Lake Geneva, WI. I am not particularly looking forward to that trip, but its to meet up with her college friends, and I don't know how long she will be able to do this, or they will still do it. They do it every other year. Thankfully, I found a ferry across Lake Michigan, so its 2 full days of driving, plus an hour, 2.5 hour ferry ride, and then another hour or so there. I think I can handle that