My mother and I have, over the years frequently exclaimed to each other "it's a sign!" when something occurs to forward or make possible something desired. We mean it light heartedly, and it is used only in a "good sign" context by us. Much as we read horoscopes - if it sounds good, hey positive sign! If a horoscope sounds not so good, well, horoscopes are not all that reliable.
For the times the universe is not strewing my desired path with roses, but with obstacles, I try (don't always succeed) to see if there are lessons to learn from the challenges, and/or evaluate if my desire to reach an objective is matched by my willingness to exert an effort, make a change, adapt - or if it shows me that I *don't* want something as much as it would cost (figuratively or literally) to get it.
In your situation, I suggest stepping back a bit from focussing on specific optional pursuits and thinking more generally about what you "want" and "why". If you find that what you want is more time to pursue creative efforts on your own, there are opportunities outside a job or teaching - but if what you want is the experience of sharing and applying your knowledge collaboratively with others and helping others develop skills, then teaching through a job, or program, whether paid or volunteer, would probably bring you more satisfaction.
You mention running your house is stressing, are there things you could "outsource" or delegate? Either hiring help with house cleaning, or getting your kids (teens?) to take on assigned organizational or logistical assignments and responsibilities? Think about the functions you most enjoy doing, and least enjoy doing and consider all options for reducing the amount of time you personally spend on things you dislike, including to what extent it would matter to you if someone took on a responsibility but did it "differently" than you would.
When you have taught classes, and felt some stress, was that offset by your enjoyment of the experience, or was the main benefit that you were trying some new activities which might lead to something you actively do enjoy?
The only "sign" I think matters immediately is that you are interested in new pursuits. You don't have to decide immediately what those new pursuits will be or consist of - and you are actively engaged in considering your options. Persevere in finding what you want to add/remove from your "plate" and make any changes you deem worthwhile which you know will further you towards your goals.