On the other hand, they have succeeded in sending the message that they are either clueless (and unwilling to be clued in) or care more about the location than the attendees.
I'd like to clarify what I meant. You all may still disagree.
They have picked a venue and time that is particularly inconvenient for many people to attend. It is their right to do so since it's their wedding, but it is still a choice. By doing so, there are two possibilities. One is that they don't realize that it's inconvenient in both time and place, which is what I meant when I said clueless. The other is that they are making a choice and saying to themselves, the location and time is very important to us, so important in fact, that we will forgo having people attend who would be able to attend a weekend wedding closer to a motel or hotel. Again, they're find to make that decision, but should recognize it for what it is.
It's kind of like what Judah said below, "When DH and got engaged we agreed that he would pick the date and I would pick the location. I picked a location that was not convenient to anyone, not my family, not his family, none of our friends, but had special meaning to me. DH picked a date almost a year and a half out that happened to fall on a holiday weekend. If you received a wedding invitation from me it was because I very much wanted you at my wedding, but understood that many people might not be able to attend. "
She knew the venue might she chose might mean that some people couldn't attend, but choosing a venue that had special meaning to her was more important than making it easier for those people to be there. It's not a slight against anyone in particular, and certainly not the same way not inviting Aunt Tilly would be to Aunt Tilly. It's about prioritizing.