My husband and I used to watch Freakazoid, which was an animated show from the same guys who created Animaniacs and Pinky and the Brain. We loved Freakazoid and were super excited when it came out on DVD. We rented one of the DVDs, settled down one Saturday night with our popcorn and adult beverages, and ... turned it off after one episode. Somehow, what was funny to us in our 20's was just plain unpleasant in our 40's.
Same for Mad About You. When we watched that in the 90's, we were newly in love, so Paul and Jaime's antics seemed very familiar to us. I tried watching it again recently, and I kept yelling "Oh, COME ON!" at the screen.