Gen xer, If something really bothers you that much, there is no reason to pretend it didn't. I think it is OK to just not respond, or to take some time. If somebody makes a crack at you that makes you feel hurt or defensive, just don't respond until you have something polite/appropriate you can say. It isn't a competition and you don't have to "win".
Our culture values glibness and quick answers, but your character is revealed by what you DO with those feelings. It is OK to be the kind of person who does not always have a glib comeback, and in fact your relationships may wind up being deeper and better because you don't sluff off feelings and keep up the "game" of banter. Your real friends, or people worth keeping in your life, will realize they have overstepped and stop "playing" so rough with you.
Have you ever read CS Lewis' quote on flippancy? "It is a thousand miles away from joy; it deadens, instead of sharpening, the intellect; and it excites no affection between those who practice it."
A lack of flippancy is no flaw. Nobody ever looked back on their deathbed and grieved all the "comebacks" they missed out on.