"Despite the FOUR no left turn signs, and the 4 signs with an arrow with a slash through it, the sign above the turn lane that points STRAIGHT people insist on turning into incoming traffic."
The flip side of this is to consider the layout. If people regularly end up driving the wrong way down a one way street, then the intersection is badly designed. Once a year is a driver error. Once a week is a fault in the markings. On a personal note, the intersection you describe is a disaster. It sounds like an invitation to gridlock. If the northbound and southbound lanes are that far separated, it should be replaced with an interchange, or a rotary, or at least a four-point so that there's less chance that someone will think turning into the oncoming lane is natural.
I'll use this to point out my entry for polite driving. While it's true that you may drive the route every day, and you're very familiar with it and the vagaries of traffic flow, consider how it may be for someone who's not familiar with it. If someone is obviously lost or confused, give them a bit of breathing room. I agree that they should pull over if they're seriously impeding traffic, but slowing down earlier than you would or making you wait for three seconds so they can find the right sign isn't going to ruin your day. If it takes you longer to take a deep breath then they take to get where they're going, be kind.