I've been wearing glasses since I was like 8, and contacts for high school and college. My eyesight is fairly bad, so my lenses are big and thick. In fact, they're thicker than my frames! Due to their size, I have lovely red marks on either side of my nose from the weight of my glasses...
Now, I used to take my glasses off for pictures when I was younger, but I realized it didn't really matter to me, so as an adult, I always wore them in pictures, unless I was like in the pool or something. My mom thought I'd take off my glasses for the wedding pictures, but I told her that was impossible, even if I wanted to, because of the red marks on my nose.
I had anti-reflection on my glasses, so there wouldn't be glare. And I've been wearing purple/pink frames for ages, so they matched the wedding colors...

So, yes, I wore my glasses, and didn't regret it.