Charlie was a member of our theatre group, and was paraplegic and so always in a wheelchair.
One day our director was on a tear during a meeting. Reaming people out right and left, cast and crew both, about things that weren't done, or not done to his satisfaction. Finally he turns to Charlie and roars "And YOU! STAND UP WHEN I'M TALKING TO YOU!!"
Charlie calmly replies "You'd just about s**t if I did"
We laughed till we cried.
More recently, I was visiting an old friend on Thanksgiving evening. His sister had died, suddenly and much too young, the week before, and her memorial service was the next day. The house was filled with friends and family, there for the holiday and the memorial. This was the first time I had been in his home since the extensive renovations he had done, so he was giving SO and I a tour. We got to the master bedroom suite, and it was a mess; unmade bed, clothes in piles everywhere. He's obviously embarassed and makes an apology for the mess, and I say "That's OK, it's not like it's Thanksgiving or anything." I'm immediately wishing my need to make a smart-alek remark would just die, but he thought that was a riot and we laughed until we cried.