We do a couple of "big shops" a month, and several small runs throughout. My neighbors don't have a car, so there's usually one trip per week where I take the neighbors while the kids are at school. I keep running lists on my cell phone of stuff that we get at each of our local stores (and the price we usually pay) so that I can see if I've found a deal.
Some things, though, I've thrown in the towel on. Life has gotten a lot busier lately, and I no longer have the time to coupon and shop like I used to. I don't buy toilet paper at the store anymore, that's on auto ship from Amazon. I buy my Ulta shower smoothies when they go on sale buy 3 get 3 free and I've got a coupon- and then I don't worry about buying bodywash for 6 months or so. Yeast, soy sauce, flour, sugar, canned tomatoes, razor blades, DH's cologne, shampoo, and laundry soap supplies get bought in 3 month to 1 year supplies when I see them at a sale price I like or we run low.