Irregular Webcomic is my absolute favorite and my home page. I like the way his jokes rely on an extenive knowledge of laungauge, mathematics, and physics... and he explains it so that you not only get the joke, but you learn something
Ozy and Millie a close second, and I also enjoy his other comic, I Drew This
I also like Dinosaur Comics at qwantz.com, and I talk about them with my Dad
I read Sluggy Freelance because this boy I really like loves the comic
I read Sam and Fuzzy whenever my brother is into it (it goes in phases)
I read the Devil's Panties because my dad does.
I'll have to look at some of these other comics you guys are mentioning. A few more updates a day might be cool